Today I was finally able to upgrade our Orion SAM server to 6.0 RC2. I did not install the first RC and installed the upgrade directly on SAM 5.5.0 (which has been upgraded since 4.0 or so). The upgrade process took a while but was flawless. I did not see any errors and I have not yet noticed any problems. I have assigned 3 machines to the AppInsight monitoring and they are polling just fine.
I'll post more in this thread if I do find any issues, but as of right now everything is great! Thanks!